Month of Birth and Thymic Output

Month of birth and thymic output.

I t is widely acknowledged that month of birth influences the risk for developing multiple sclerosis (MS) later in life. This has been consistently shown in a number of countries and regions including England, Scotland, Canada, Denmark, Sweden, Sardinia, Finland, and Australia (eReferences, http://www.jamaneuro.com). The month of birth effect is particularly evident in England, where the risk f...

Thymic output in aged mice.

Using GFP to mark recent thymic emigrants (RTEs) in mice carrying a GFP transgene driven by the recombination-activating gene 2 promoter, we demonstrate that RTEs are readily detectable even in 2-year-old mice, despite the fact that the proportion of the peripheral T cell pool comprised of RTEs declines with age. Although the number of RTEs decreases after reaching a peak at 6 weeks of age, thy...

Thymic output: influence factors and molecular mechanism.

Thymus is a primary lymphoid organ, able to generate mature T cells that eventually colonize secondary lymphoid organs, and is therefore essential for peripheral T cell renewal. Recent data showed that normal thymocyte export can be altered by several influence factors including several chemokines, sphingosine1-phosphate (S1P), transcription factors such as Foxj1, Kruppel-like transcription fac...

Month of Birth and the Incidence of Multiple Sclerosis in Southern Iran

Month of birth, hemisphere of birth and schizophrenia.

BACKGROUND To assess quarterly fluctuations in schizophrenia births in a southern hemisphere data set, and to compare the quarterly birth distributions of patients born in the northern and southern hemisphere. METHOD The month and place of birth of patients with schizophrenia (n = 9348) were extracted from a mental health register. RESULTS The quarterly birth distribution of patients with s...